The Journal of Mathematical Biology fosters the contribution of mathematical modeling and reasoning to the understanding of biological systems and the explanation of biological phenomena. The journal also serves as a forum for the presentation of biologically inspired problems of a mathematical nature.

Published papers provide biological insight as a result of mathematical analysis or identify and open up challenging new types of mathematical problems derived from biological knowledge.

Areas of biology covered include, biofluids, cell biology, physiology, neurobiology and behaviour, development, ecology, population biology, genetics and evolution, epidemiology, immunology, molecular biology, DNA and protein structure and function, and more.